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    Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell-Cycle Arrest and Premature Senescence in Adult Mice

    February 2024 in “ Journal of Investigative Dermatology ”
    Marloes Jonkhout, Tijs Vanhessche, Mónica Ferreira … Mathieu Bollen
    Studysummary In this study, the deletion of NIPP1 in keratinocytes led to chronic skin inflammation and epidermal changes in mice, with early cell-cycle arrest and premature senescence observed, potentially contributing to reduced mutagen sensitivity.
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    Research cited in this study 9

    1. Studying Hair Growth Cycle and Its Effects on Mouse Skin Journal of Investigative Dermatology · 2023
    2. SIRT7 Activates Quiescent Hair Follicle Stem Cells to Ensure Hair Growth in Mice EMBO journal · 2020
    3. Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2020
    4. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012
    5. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    6. EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair Genes & Development · 2011
    7. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    8. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    9. The Hair Cycle Journal of Cell Science · 2006

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