Microbial Dysbiosis and Its Diagnostic Potential in Androgenetic Alopecia: Insights from Multi-Kingdom Sequencing and Machine Learning

    May 2025 in “ mSystems ”
    Xiaochen Wang, Fengjuan Li, Yangyang Sun … Xiaoquan Su
    Studysummary This study discovered that androgenetic alopecia disrupts the scalp microbiome balance across the whole scalp, not just areas with hair loss, and introduced a microbial index for early detection and severity prediction.
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    Research cited in this study 17

    1. Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia Microorganisms · 2021
    2. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    3. Investigation on Microecology of Hair Root Fungi in Androgenetic Alopecia Patients Mycopathologia · 2019
    4. Microbiome in the Hair Follicle of Androgenetic Alopecia Patients PLOS ONE · 2019
    5. Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness Nature Communications · 2018
    6. Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health Frontiers in cellular and infection microbiology · 2018
    7. The Contribution of Endogenous and Exogenous Factors to Male Alopecia Plastic and Reconstructive Surgery · 2013
    8. The Association of Insulin Resistance and Metabolic Syndrome in Early Androgenetic Alopecia PubMed · 2010
    9. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    10. Prevalence and Types of Androgenetic Alopecia in Shanghai, China: A Community-Based Study British Journal of Dermatology · 2009
    11. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    12. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    13. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003
    14. Current and Novel Methods for Assessing Efficacy of Hair Growth Promoters in Pattern Hair Loss Journal of The American Academy of Dermatology · 2003
    15. Nutritional Factors and Hair Loss Clinical and Experimental Dermatology · 2002
    16. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    17. Guidelines of Care for Androgenetic Alopecia Journal of The American Academy of Dermatology · 1996

    Related research 3

    1. Revitalizing Hair Growth: A New Regimen Utilizing Growth Factor Concentrate for Hair Loss Treatment Cureus · 2024
    2. Significant Relationship Between Temporal Hair Loss and Other Scalp Areas in Female Pattern Hair Loss Journal of Dermatology · 2020
    3. The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis International Journal of Dermatology · 2008