Low Fucosylation Defines the Glycocalyx of Progenitor Cells and Melanocytes in the Human Limbal Stem Cell Niche

    December 2024 in “ Stem Cell Reports ”
    Ashley M. Woodward, Damien Guindolet, Rafael Martínez-Carrasco … Pablo Argüeso
    Studysummary In this study, researchers observed that low levels of fucose-binding lectin staining characterize limbal epithelial progenitor cells, which maintain a high proliferative capacity and may be enhanced by inhibiting fucosylation, offering insights for regenerative therapy of the limbal stem cell niche.
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    Research cited in this study 4

    1. Regulation of Adult Stem Cell Quiescence and Its Functions in the Maintenance of Tissue Integrity Nature Reviews Molecular Cell Biology · 2023
    2. LGR5 Is a Conserved Marker of Hair Follicle Stem Cells in Multiple Species and Is Present Early and Throughout Follicle Morphogenesis Scientific Reports · 2022
    3. Cell Fate Decisions: Emerging Roles for Metabolic Signals and Cell Morphology EMBO Reports · 2017
    4. Epigenetic Control of Adult Stem Cell Function Nature Reviews Molecular Cell Biology · 2016