A Preliminary Study of Markers for Human Hair Follicle Melanin Stem Cells

    March 2019 in “ Chinese Medical Journal ”
    Xingyu Mei, Zhouwei Wu, Ken Chen, Yue Sun, Weimin Shi
    Image of study
    TLDR Researchers identified potential markers for human hair color stem cells.
    In the 2019 study, researchers analyzed foreskin tissue samples from 9 individuals to identify markers for human hair follicle melanin stem cells (MSCs) and hair follicle stem cells (HFSCs). They used flow cytometry to detect these cells, employing PAX3 and CD34 as markers. The results showed that 4.82±0.15% of cells were PAX3+, 5.38±0.21% were CD34+, and 0.58±0.05% were both PAX3+ and CD34+. Further analysis revealed that PAX3+/CD34+ cells had a similar expression of TRP-2 to the control group but significantly lower expression of other melanocyte markers. Immunofluorescence confirmed the presence of TRP-2 on PAX3+/CD34+ cells, while MITF and Melan-A were not expressed. The study concluded that the phenotype PAX3+/CD34+/TRP-2+/MITF-/Melan-A- could serve as candidate markers for MSCs. The study was funded by the National Natural Science Foundation of China.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community How soon is hair clone? Next five years?!

      in Research/Science  15 upvotes 4 months ago
      Hair cloning is humorously discussed as always being 5-7 years away, with skepticism about its near-term availability. Gene editing to reactivate dormant follicles is suggested as a more likely solution within the next ten years.

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  301 upvotes 1 year ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

      community Fighting Hair loss AND Grey Hair

      in Treatment  18 upvotes 2 years ago
      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

    Related Research

    1 / 1 results