Characterization of Murine Excisional Wounds Using Atomic Force Microscopy Indentation

    July 2025 in “ Acta Biomaterialia ”
    H. Junker, Adam Wahlsten, Raoul Hopf … Edoardo Mazza
    Studysummary In this study, AFM-based indentation was used to assess mechanical properties of murine skin wounds at two healing stages, revealing that early wounds exhibit stiffer hyperproliferative epithelium compared to granulation tissue, and highlighting significant influences of surface roughness on tissue stiffness measurements.
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    Research cited in this study 2

    1. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    2. Wound Healing: A Cellular Perspective Physiological Reviews · 2018