MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen<sup>1</sup>

May 1997 in “ The Journal of Clinical Endocrinology & Metabolism ”

Jules I. Schwartz, Wesley Tanaka, Daniel Z. Wang, David L. Ebel, Lori Geissler, Aimée Dallob, Barry Hafkin, Barry J. Gertz

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Research cited in this study

9 / 9 results

Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

research Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

6 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

research Clinical Review 73: Medical Treatment of Androgen-Dependent Hirsutism

24 citations , September 1995 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Medication and hair removal methods can improve hirsutism, but no drugs were specifically approved for it in North America as of 1995.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations , October 1992 in “The New England Journal of Medicine”

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers

147 citations , April 1990 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride safely lowers DHT levels without affecting testosterone.

research Correlation of Serum 3α-Androstanediol Glucuronide with Acne and Chest Hair Density in Men

51 citations , November 1988 in “The Journal of Clinical Endocrinology & Metabolism”

Higher levels of a specific hormone are linked to more chest hair and acne in men.

research 3 Alpha, 17 Beta-Androstanediol Glucuronide in Plasma: A Marker of Androgen Action in Idiopathic Hirsutism

179 citations , May 1982 in “The Journal of clinical investigation/The journal of clinical investigation”

High levels of 3 alpha-diol glucuronide in the blood are a marker of increased androgen action in women with excessive hair growth of unknown cause.

research Testosterone Metabolism in the Skin

74 citations , November 1975 in “Archives of dermatology”

Increased DHT formation in skin can cause hair loss, acne, and excessive hair growth, and antiandrogens might treat these conditions.

Testosterone Metabolism in the Skin: A Review of Its Function in Androgenetic Alopecia, Acne Vulgaris, and Idiopathic Hirsutism Including Recent Studies with Antiandrogens

research Testosterone Metabolism in the Skin: A Review of Its Function in Androgenetic Alopecia, Acne Vulgaris, and Idiopathic Hirsutism Including Recent Studies with Antiandrogens

43 citations , November 1975 in “Archives of Dermatology”

Testosterone affects hair loss, acne, and excessive hair growth, and antiandrogens can help treat these conditions.

Related Research

6 / 6 results

research 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety

19 citations , April 2020 in “Dermatologic Therapy”

Dutasteride works better than finasteride for hair loss, with both being safe to use.

research A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits

June 2019 in “Journal of Drug Delivery and Therapeutics”

Finasteride effectively treats hair loss and prostate issues with minimal side effects.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations , October 1999 in “Journal of The American Academy of Dermatology”

Finasteride effectively reduces hair loss by decreasing androgen levels.

A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

research A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

60 citations , December 1998 in “Clinical Pharmacology & Therapeutics”

Both drugs lower DHT levels, with GI198745 being more effective.

research Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

7 citations , August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness

61 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”