Mitochondrial Dysfunction in Lichen Planopilaris with Focus on Oxidative Stress and Metabolic Reprogramming

This document discusses Lichen Planopilaris (LPP), an inflammatory primary cicatricial alopecia characterized by scarring hair loss. The exact cause of LPP is unknown, but it is considered a follicular variant of lichen planus due to histopathological findings of lichenoid perifollicular inflammation. LPP is the most common cause of scarring hair loss, with a prevalence of 13.4 per 100,000 patients. It manifests in three forms: classic LPP, frontal fibrosing alopecia (FFA), and Graham-Little-Piccardi-Lasseur syndrome (GLPLS). Classic LPP is marked by irregular hair loss patterns. The study focuses on mitochondrial dysfunction, oxidative stress, and metabolic reprogramming in LPP.