Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells
March 1998
in “British Journal of Dermatology”
TLDR Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.
Minoxidil increases the expression of vascular endothelial growth factor (VEGF) in human hair dermal papilla cells, which may promote hair growth during the anagen phase of the hair cycle. The increase in VEGF mRNA expression was dose-dependent, with DPC stimulated with 24 µmol/L minoxidil expressing six times more VEGF mRNA than controls. This suggests that minoxidil may play a role in the development of dermal papilla and treating androgenetic alopecia. Minoxidil may promote hair growth by inducing the formation of new blood vessels and stimulating VEGF production in hair follicles.
View this study on academic.oup.com →
Cited in this study
research Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells
research Topical minoxidil in early male pattern baldness
Minoxidil promotes hair growth in male pattern baldness.
Related
research Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production
Chicken egg yolk peptides can promote hair growth by increasing a specific growth factor.
research Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Researchers developed a 3D model of human hair follicle cells that can help understand hair growth and test new hair loss treatments.
research Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice
Geranium sibiricum extract helps hair grow and is more effective than minoxidil but can be toxic in high concentrations.
research Minoxidil activates β-catenin pathway in human dermal papilla cells: A possible explanation for its anagen prolongation effect
Minoxidil helps hair growth by activating the β-catenin pathway.
research Control of hair growth and follicle size by VEGF-mediated angiogenesis
VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
research Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells
Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.
research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action
Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.