Minoxidil-Induced Cardiac Hypertrophy in Guinea Pigs

    May 1999 in “ Cellular and Molecular Life Sciences ”
    Jolanda van der Velden, P. Borgdorff, Ger J.M. Stienen
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    TLDR Minoxidil may cause heart issues in guinea pigs, suggesting potential harm for users with heart conditions.
    The study found that minoxidil, a drug used for hair loss treatment, can cause cardiac hypertrophy in guinea pigs, indicating potential harm to the heart. The drug can lead to changes in heart muscle properties, weight, and composition, and caution is advised when using it in patients with pre-existing cardiovascular conditions. Higher doses of minoxidil can lead to greater increases in heart weight, and the condition developed gradually with low mortality rates. The drug may have potential cardiovascular side effects, and long-term use can cause eccentric left ventricular hypertrophy due to volume overload.
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      community What's "wrong" with oral minoxidil, exactly?

      in Minoxidil  173 upvotes 2 months ago
      Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

      community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

      in Minoxidil  178 upvotes 1 month ago
      Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

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