Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension
May 2004
in “Journal of Clinical Hypertension”
TLDR Minoxidil effectively treats severe hypertension, but watch for side effects.
The article discusses the use of minoxidil as a vasodilator for the treatment of resistant or severe hypertension. While it can effectively lower blood pressure, there are potential side effects such as reflex tachycardia, elevated pulmonary artery pressures, and hypertrichosis (excessive hair growth). The authors conclude that minoxidil is an effective treatment option for resistant or severe hypertension, but caution that its use should be carefully monitored due to the potential for side effects.
View this study on onlinelibrary.wiley.com →
Cited in this study
research Minoxidil: mechanisms of action on hair growth
Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.
research Topically applied minoxidil may cause fetal malformation: A case report
Minoxidil use during pregnancy may cause fetal harm.
research Generalized hypertrichosis after treatment with topical minoxidil
Too much topical minoxidil can cause excessive hair growth, but stopping treatment reverses it.
research Hair loss with minoxidil withdrawal
Stopping minoxidil caused significant hair loss, but regrowth occurred after resuming use.
research Topical minoxidil: cardiac effects in bald man.
Using topical minoxidil for baldness can cause heart problems, especially in those with heart disease.
research Minoxidil: a review of its pharmacological properties and therapeutic use.
Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.
research Minoxidil and pericardial effusion: An idiosyncratic reaction
Minoxidil can cause dangerous fluid buildup around the heart.
research Minoxidil
Minoxidil controls blood pressure effectively, but may cause side effects like hypertrichosis.
research Renal Function During Long-Term Treatment of Hypertension with Minoxidil
Long-term use of minoxidil for high blood pressure can delay kidney failure in some patients and improve kidney function in others with severe hypertension.
research Pericardial Disorders Occurring During Open-Label Study of 1,869 Severely Hypertensive Patients Treated with Minoxidil
Minoxidil doesn't increase pericardial disorder risk, but may cause fluid accumulation.
research Hypertrichosis due to minoxidil
Minoxidil causes excessive hair growth in almost all patients.
research Treatment of Severe Hypertension with Minoxidil: Advantages and Limitations
Minoxidil effectively controls blood pressure but side effects may limit its use.
research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs
Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.
research A method for achieving blood pressure control expeditiously with oral minoxidil
Oral minoxidil effectively controls blood pressure quickly and safely.
research Minoxidil — An Alternative to Nephrectomy for Refractory Hypertension
Minoxidil effectively lowers blood pressure with few side effects.
research Pharmacokinetic studies of minoxidil
Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.