MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

The study investigates the mechanical properties of hair follicle stem cells (SCs) and their role in hair regeneration. It finds that hair follicle SCs in the bulge are stiff with high actomyosin contractility, while hair germ (HG) progenitors are softer and undergo size changes during quiescence. Activation of hair follicle growth involves HGs reducing contraction and enlarging more frequently, linked to a weakened actomyosin network and cell cycle reentry. The induction of microRNA-205 (miR-205) reduces actomyosin contractility and stimulates hair regeneration in both young and old mice. This research highlights the potential to enhance tissue regeneration by adjusting the mechanical properties of cells.