Development and Evaluation of Formulations of Microbial Biotransformed Extract of Tobacco Leaves for Hair Growth Potential

The study investigated the hair growth effects of a microbial biotransformed extract of tobacco leaves on male albino Wistar rats. The extract was obtained by fermenting tobacco leaves in cow urine for 28 days and then incorporated into herbal lotions at concentrations of 10%, 20%, and 30%. These lotions were applied to the rats' shaved skin for 30 days. The results indicated a concentration-dependent improvement in hair growth and an increase in serum total protein, alongside a reduction in serum total testosterone. The findings suggest that the tobacco leaf extract has the potential to promote hair growth and could be useful in treating alopecia, but the study called for more research to understand the underlying mechanisms and confirm safety and efficacy for clinical use. The number of rats used in the study was not mentioned.