Metformin: Old Drug, New Therapeutic Potential in the Skin? A Brief Narrative Review

Topical Metformin shows potential for regenerating hair follicles and minimizing scarring in hair transplant donor areas, similar to Verteporfin but without its side effects. The discussion suggests considering Metformin for post-hair transplant care, though more human trials are needed.

The conversation is about whether it's safe to take Metformin for weight loss and Finasteride together, with the concern that Finasteride is not commonly used for hair loss treatment in the user's location, and their doctor is not knowledgeable about it.

Akkermansia bacteria can improve hair growth inhibited by testosterone, and metformin may increase Akkermansia, which could help with hair loss related to aging, insulin resistance, and inflammation.

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

Finasteride may affect blood sugar and metabolism, with some users reporting increased blood sugar and changes in body composition. To manage potential side effects, users suggest exercise, intermittent fasting, and dietary adjustments.

Using DIM and Calcium D-Glucarate to reduce finasteride side effects. Discussion includes dosage, brand, and product effectiveness.