Gradients of Mesenchymal Stiffness Control Sweat Gland Cell Fate Specification During Morphogenesis

November 2025 in “ Journal of Investigative Dermatology ”

Chuang Lu, Jian Tong

mesenchymal stiffness sweat gland morphogenesis sweat placode progenitors dermis ductal growth glandular growth Wnt expression fibroblasts tissue stiffness microfluidic device Wnt gradient ductal-to-glandular fate transition mechanical cues biochemical cues mesenchymal niche epidermal progenitors skin regeneration sweat gland development Wnt signaling fibroblast activity

Studysummary Mesenchymal stiffness affects sweat gland cell development.

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