Influence of the Stiffness of Three-Dimensionally Bioprinted Extracellular Matrix Analogue on the Differentiation of Bone Mesenchymal Stem Cells into Skin Appendage Cells

    November 2020 in “ PubMed ”
    Enhejirigala, Y J Zhang, J J Li, Bin Yao, Wei Song, Sha Huang, Xiaobing Fu
    TLDR Stiffer hydrogels better promote stem cells turning into hair follicle cells.
    The study investigated the effect of the stiffness of bioprinted extracellular matrix analogues on the differentiation of bone marrow mesenchymal stem cells (BMSCs) into skin appendage cells. Two hydrogels, 1A4G and 3A8G, with different stiffness levels were used. The 3A8G hydrogel, which had a higher stiffness (218±5 kPa), showed a stronger tendency to promote BMSCs differentiation into hair follicle cells compared to the 1A4G hydrogel (52±6 kPa). Both hydrogels supported the differentiation into sweat gland cells, but the higher stiffness of the 3A8G hydrogel was more conducive to hair follicle cell differentiation. This suggests that the stiffness of the extracellular matrix plays a crucial role in directing stem cell differentiation into specific skin appendage cells.
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