Influence of the Stiffness of Three-Dimensionally Bioprinted Extracellular Matrix Analogue on the Differentiation of Bone Mesenchymal Stem Cells into Skin Appendage Cells

    November 2020 in “ PubMed ”
    Enhejirigala, Y J Zhang, J J Li, Bin Yao, Wei Song, Sha Huang, Xiaobing Fu
    TLDR Stiffer hydrogels better promote stem cells turning into hair follicle cells.
    The study explored how the stiffness of three-dimensionally bioprinted extracellular matrix analogues influenced the differentiation of bone marrow mesenchymal stem cells (BMSCs) into skin appendage cells. Using two hydrogels, 1A4G and the stiffer 3A8G, it was found that BMSCs in both hydrogels tended to differentiate into sweat gland cells. However, the stiffer 3A8G hydrogel promoted a stronger differentiation into hair follicle cells, indicating that increased stiffness in the bioprinted matrix enhanced differentiation into both sweat gland and hair follicle cells. The study used 20 C57BL/6 mice for BMSC isolation.
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