Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

    February 1998 in “Analytical Chemistry
    Bogdan J. Matuszewski, M.L Constanzer, Cynthia Chavez-Eng
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    TLDR Method detects finasteride in plasma at very low concentrations.
    This document discusses the challenges of accurately measuring the concentration of finasteride in human plasma using LC/MS/MS analysis due to the matrix effect. The authors propose various methods to address this issue, including selective extraction and improved chromatography. The study emphasizes the importance of studying the matrix effect in quantitative analyses of biological fluids. The method presented in the paper can detect finasteride at picogram per milliliter concentrations in human plasma. However, the document does not provide information on the effectiveness of finasteride in treating hair loss or alopecia.
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