Mast Cell-5-HT-HTR2A Axis Involvement in Chronic Itch Induced by SADBE

December 2025 in “ Molecular Pain ”

Fan Limin, Xiuyu Nong, Manting Ni … Xueting Liu

mast cell 5-hydroxytryptamine 5-HT 5-HT2A HTR2A chronic pruritus squaric acid dibutyl ester SADBE allergic contact dermatitis ACD mast cell stabilizer HTR2A antagonist FcεRIα-KO mice IgE-dependent 5-HT release single-cell RNA sequencing in situ hybridization sensory neurons serotonin itch antihistamine allergy RNA sequencing

Studysummary This study identified that the MC-5-HT-HTR2A axis plays a role in chronic pruritus in a mouse model of SADBE-induced allergic contact dermatitis, suggesting potential for therapeutic targeting.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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