Male androgenetic alopecia
July 2002
in “Clinical and Experimental Dermatology”
TLDR DHT, a testosterone byproduct, causes male pattern baldness.
This document from 20 years ago discusses male androgenetic alopecia (AGA), also known as male pattern baldness. The paper explores the effects of androgens on hair growth and the pathogenesis of AGA. The study found that hair follicles in certain areas of the body are androgen-dependent, and that the principal mediator of androgen-dependent hair loss is DHT, the 5α-reduced metabolite of testosterone. The paper also discusses the role of androgen metabolism in hair growth and the conversion of weak androgens to more potent androgens. The study concludes that further research is needed to fully understand the mechanisms behind AGA.
View this study on academic.oup.com →
Cited in this study
research An X-Linked Gene Involved in Androgenetic Alopecia: A Lesson to Be Learned from Adrenoleukodystrophy
Gene linked to common hair loss found, may lead to new treatments.
research Finasteride is the main inhibitor of 5α-reductase activity in microdissected dermal papillae of human hair follicles
Finasteride potentially treats hair loss by reducing DHT production.
research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factor(s) in Response to Testosterone Unlike Scalp Cells
Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.
research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne
Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.
research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia
People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque1
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
research Mechanism of action of androgen in hair follicles
Testosterone affects hair follicles differently across body sites, with beard hair follicles showing more activity of a specific enzyme and presence of androgen receptors compared to scalp hair.
research Reduced Linear Hair Growth Rates of Vellus and of Terminal Hairs Produced by Human Balding Scalp Grafted onto Nude Mice
research Animal models of androgen-dependent disorders of the pilosebaceous apparatus
Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
research The effect of testosterone, cyproterone acetate, and minoxidil on hair loss in the androchronogenetic alopecia mouse
The mouse model could be useful for baldness research and testing treatments like testosterone, cyproterone acetate, and minoxidil.
research Action of topical minoxidil in the bald stump-tailed macaque
Minoxidil promotes hair growth but stops working when discontinued.
Related
research Acitretin for the Treatment of Psoriasis: A Case Report of Long-Lasting Alopecia
A patient experienced long-lasting hair loss after using acitretin for psoriasis.
research Disorders of Hair
The document's conclusion cannot be provided because the document is not readable or understandable.
research Male androgenetic alopecia
DHT, a testosterone byproduct, causes male pattern baldness.
research CLINICAL UPDATES IN HAIR
Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.
research ANDROGEN METABOLISM AS IT AFFECTS HAIR GROWTH IN ANDROGENETIC ALOPECIA
Too much androgen can cause hair loss; finasteride may help.