Twist1 Is Required for the Development of UVB-Induced Squamous Cell Carcinoma

March 2021 in “ Molecular Carcinogenesis ”

Fernando Eguiarte‐Solomon, Nicholas Blazanin, Okkyung Rho, Steve Carbajal, Dean W. Felsher, Phuoc T. Tran, John DiGiovanni

Twist1 UVB-induced skin carcinogenesis keratinocytes epidermal hyperproliferation keratinocyte differentiation TG1 K1 OVOL1 loricrin filaggrin hair follicle stem/progenitor markers cutaneous squamous cell carcinoma

Studysummary This study found that deleting the transcription factor Twist1 in keratinocytes significantly reduced UVB-induced skin carcinogenesis in mice, suggesting a potential target for preventing cutaneous squamous cell carcinoma.

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