Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation

November 2012 in “ Expert Opinion on Drug Safety ”

Serap Gür, Philip J. Kadowitz, Wayne J.G. Hellstrom

5-alpha reductase inhibitors finasteride dutasteride benign prostatic hyperplasia androgenic alopecia erectile dysfunction sexual desire orgasmic issues ejaculatory dysfunction 5ARIs Propecia Avodart BPH AA ED

From the encyclopedia

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Dutasteride →

Heavy duty finasteride that comes with higher risks

Studysummary This article reviews the reported sexual and psychological side effects of 5-alpha reductase inhibitors for benign prostatic hyperplasia, emphasizing the need for further clinical studies.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document from November 22, 2012, reviews the sexual side effects of 5-alpha reductase inhibitors (5ARIs), specifically finasteride and dutasteride, which are used to treat benign prostatic hyperplasia (BPH) and androgenic alopecia (AA). It reports that these drugs are associated with a prevalence of de novo erectile dysfunction (5-9%), reduced sexual desire, and orgasmic issues, with some studies indicating persistent sexual dysfunction after discontinuation. The document cites clinical trials and regulatory agency updates, noting that sexual dysfunction rates with finasteride range from 0.8% to 15.8%, and persistent effects can last over 6 years for some patients. Ejaculatory dysfunction is less studied. The need for future research to understand the mechanisms and develop prevention and treatment strategies is emphasized, as well as the importance of informed patient counseling regarding these potential adverse effects.

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