Left Ventricular Myocardial Mass Index and Its Correlates as an Early Marker of Cardiovascular Risk Among Nonobese Normotensive Indian Women With Polycystic Ovary Syndrome: Lessons From a Cross-Sectional Study

June 2020 in “ Fertility and Sterility ”

Aafia Rashid, Muhammad Akbar, Idrees Ahmed Wani, Imran Hafeez, Tabasum Parvez, Mohd Afzal Zagar, Mohd Ashraf Ganie

polycystic ovary syndrome PCOS insulin resistance IR inflammatory markers hyperandrogenism

TLDR Nonobese, normotensive Indian women with PCOS may have a higher risk of heart problems linked to inflammation and insulin resistance.

In a cross-sectional study from June 2020 involving 260 nonobese, normotensive Indian women with polycystic ovary syndrome (PCOS) and 250 healthy controls, it was found that the PCOS group had a significantly higher left ventricular myocardial mass index (LVMI) than the control group. The study also revealed that women with PCOS had higher levels of insulin resistance (IR) and inflammatory markers, which were positively correlated with LVMI, but not with hyperandrogenism. These findings suggest that nonobese, normotensive women with PCOS may have an increased risk of cardiovascular issues, associated more with inflammation and IR than with androgen excess. The authors recommend further long-term studies with larger cohorts to better assess cardiovascular risk in this population.

View this study on fertstert.org →

Discuss this study in the Community →

Cited in this study

7 / 7 results

research Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome Consuming Vegetarian vs. Non-Vegetarian Diet

28 citations , November 2019 in “Frontiers in Endocrinology”

Vegetarian Indian women with PCOS have higher inflammation levels than non-vegetarians.

research Oral Glucose Tolerance Test Significantly Impacts the Prevalence of Abnormal Glucose Tolerance Among Indian Women With Polycystic Ovary Syndrome: Lessons From a Large Database of Two Tertiary Care Centers on the Indian Subcontinent

22 citations , January 2016 in “Fertility and Sterility”

The oral glucose tolerance test is effective in detecting abnormal glucose tolerance in Indian women with PCOS.

research High-Sensitivity C-Reactive Protein Levels and Their Relationship with Components of Polycystic Ovary Syndrome in Indian Adolescent Women with PCOS

21 citations , August 2014 in “Gynecological Endocrinology”

Higher hs-CRP levels in Indian adolescent women with PCOS are more related to BMI than PCOS itself.

research Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis

991 citations , January 2011 in “Nature Reviews Endocrinology”

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

research Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

815 citations , May 2010 in “The Journal of Clinical Endocrinology & Metabolism”

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

research Left Ventricular Function in Patients with Polycystic Ovary Syndrome: A Doppler Echocardiographic Study

13 citations , September 2008 in “Experimental and Clinical Endocrinology & Diabetes”

Young women with PCOS without additional risk factors may have normal heart function.

research Endothelial Dysfunction in PCOS: Role of Obesity and Adipose Hormones

155 citations , April 2006 in “The American Journal of Medicine”

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.