Left Ventricular Myocardial Mass Index and Its Correlates as an Early Marker of Cardiovascular Risk Among Nonobese Normotensive Indian Women With Polycystic Ovary Syndrome: Lessons From a Cross-Sectional Study

    May 2020 in “ Fertility and Sterility ”
    Aafia Rashid, Muhammad Akbar, Idrees Ahmed Wani, Imran Hafeez, Tabasum Parvez, Mohd Afzal Zagar, Mohd Ashraf Ganie
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    TLDR Nonobese, normotensive Indian women with PCOS may have a higher risk of heart problems linked to inflammation and insulin resistance.
    In a cross-sectional study from June 2020 involving 260 nonobese, normotensive Indian women with polycystic ovary syndrome (PCOS) and 250 healthy controls, it was found that the PCOS group had a significantly higher left ventricular myocardial mass index (LVMI) than the control group. The study also revealed that women with PCOS had higher levels of insulin resistance (IR) and inflammatory markers, which were positively correlated with LVMI, but not with hyperandrogenism. These findings suggest that nonobese, normotensive women with PCOS may have an increased risk of cardiovascular issues, associated more with inflammation and IR than with androgen excess. The authors recommend further long-term studies with larger cohorts to better assess cardiovascular risk in this population.
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