TLDR Low-dose tofacitinib is effective and cheaper for severe alopecia areata.
The study explored the use of low-dose tofacitinib as a treatment for severe alopecia areata (AA), highlighting its potential as an efficient and cost-saving regimen. Tofacitinib, a selective Janus kinase (JAK) 1 and 3 inhibitor, had been previously used at higher dosages of 10 to 20 mg daily for treating severe AA. However, the study aimed to evaluate the therapeutic response of a lower-dosage regimen, which had not been thoroughly assessed before. The lower dosage was suggested to offer clinical advantages, such as reduced medical costs and fewer potential adverse effects, making it a promising alternative for patients with severe AA.
130 citations
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February 2018 in “Journal of Investigative Dermatology” Tofacitinib may help treat severe hair loss, but more research is needed.
24 citations
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January 2018 in “International Journal of Trichology” Tofacitinib helped regrow hair in patients with alopecia, with few side effects.
49 citations
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March 2017 in “Journal of the American Academy of Dermatology” Tofacitinib caused significant hair regrowth in adolescents with alopecia universalis who didn't respond to other treatments.
139 citations
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November 2016 in “Journal of the American Academy of Dermatology” Tofacitinib helped regrow hair in most adolescents with alopecia areata, but more research is needed.
238 citations
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November 2016 in “Journal of The American Academy of Dermatology” Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.
222 citations
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September 2016 in “JCI insight” Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.
51 citations
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June 2016 in “Journal of the European Academy of Dermatology and Venereology” Tofacitinib was effective in treating hair loss in two patients with alopecia universalis.
Tofacitinib helped a woman with total-body hair loss grow her hair back.
October 2022 in “Journal of Armed Forces Medical College, Bangladesh” Tofacitinib is effective and safe for treating alopecia areata.
4 citations
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July 2018 in “PubMed” Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.
16 citations
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July 2017 in “Rheumatology and Therapy” Tofacitinib, a medication for arthritis, showed potential for treating severe hair loss in a small Brazilian case series, but more research is needed.
16 citations
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January 2017 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” A patient with complete hair loss regrew all her hair using tofacitinib.
5 citations
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June 2015 in “Veterinary dermatology” A dog with complete hair loss regrew most hair after treatment, with no relapse after stopping treatment.
