Lifestyle Intervention and Anti-Obesity Therapies in Polycystic Ovary Syndrome: Impact on Metabolism and Fertility

April 2013 in “ Endocrine ”

Dimitrios Panidis, Konstantinos Tziomalos, Efstathios Papadakis, Christos Vosnakis, Panagiotis Chatzis, Ilias Katsikis

polycystic ovary syndrome PCOS lifestyle intervention diet exercise behavioral modification anti-obesity pharmacotherapy metabolic abnormalities reproductive abnormalities endocrine abnormalities orlistat sibutramine rimonabant anti-obesity drugs

TLDR Lifestyle changes improve metabolism and fertility in overweight PCOS patients; anti-obesity drugs show potential but need more research.

The document from April 27, 2013, reviewed the effects of lifestyle interventions and anti-obesity pharmacotherapy on patients with polycystic ovary syndrome (PCOS), focusing on metabolic and fertility outcomes. Lifestyle changes such as diet, exercise, and behavioral modification were found to improve metabolic and reproductive abnormalities in overweight and obese PCOS patients, making these the first-line management strategy. Although the optimal diet and exercise types are unknown, lifestyle changes alone or combined with anti-obesity drugs can benefit endocrine abnormalities and metabolic parameters. Anti-obesity drugs like orlistat showed promise, but data on their efficacy in PCOS are limited, and other drugs like sibutramine and rimonabant were withdrawn due to side effects. The document did not provide the number of participants in the reviewed studies.

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