Level-1 Data From the REDUCE Study and the PCPT Data

October 2015 in “ Prostate Cancer ”

Goutham Vemana, Gerald L. Andriole

5-alpha-reductase inhibitors finasteride dutasteride prostate cancer PSA Propecia Avodart

TLDR Finasteride and dutasteride reduce prostate cancer risk, but finasteride may increase higher-grade cancer risk.

The document discussed two major studies evaluating the impact of 5-alpha-reductase inhibitors on prostate cancer risk. The Prostate Cancer Prevention Trial focused on men with low baseline PSA levels and found that finasteride significantly reduced the risk of prostate cancer detection, although it was associated with an increased diagnosis of higher-grade disease. The REDUCE trial examined the effects of dutasteride in men with elevated PSA levels, showing a significant reduction in prostate cancer risk without a statistical increase in higher-risk disease compared to placebo.

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Research cited in this study

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research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

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5alpha-reductase inhibitors like finasteride and dutasteride effectively treat BPH by reducing DHT, offering symptom relief and potential future uses.

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The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

1054 citations , February 1998 in “The New England Journal of Medicine”

Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.

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Dutasteride: A Review of Its Use in the Management of Prostate Disorders

Level-1 Data From the REDUCE Study and the PCPT Data

Research cited in this study

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

research 5alpha-Reductase: History and Clinical Importance

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

research 5α-Reductase Activity in the Prostate

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

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