Krox20 in Epithelial and Glial Stem Cells and Their Niches

January 2019 in “ Advances in stem cells and their niches ”

Chung-Ping Liao, Edem Tchegnon, Lu Q. Le

Krox20 hair follicle stem cell niche Wnt/β-catenin BMP Notch stem cell quiescence stem cell activation hair shaft formation pigmentation SCF-KIT signaling melanocytes

Studysummary Krox20 is important for cell differentiation in the brain and hair follicles.

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research Identification of Hair Shaft Progenitors That Create a Niche for Hair Pigmentation

44 citations , April 2017 in “Genes & development”

This study identified hair shaft progenitors in the matrix that regulate hair growth and pigmentation by creating a niche dependent on stem cell factor, implicating KROX20+ cells in these processes.

research Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

This study found that Sonic Hedgehog secreted by hair follicle transit-amplifying cells is essential for dermal adipogenesis and hair follicle growth by acting on adipocyte precursors.

research Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying

30 citations , April 2013 in “Journal of Investigative Dermatology”

This study found that ionizing radiation primarily affects keratinocyte stem cells in the hair follicle, suggesting they play a central role in radiation-induced hair graying, rather than melanocyte stem cells.

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations , June 2011 in “Cell”

This study found that Wnt signaling in the hair follicle is crucial for coordinating the behavior of epithelial and melanocyte stem cells, which drives hair regeneration and melanocyte differentiation in mice.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

In this study, researchers found that hair follicle stem cells in mice can generate both hair follicle and epidermis cells, highlighting their potential bipotency.