Identification of the C-Terminal Tail Domain of AHF/Trichohyalin as the Critical Site for Modulation of the Keratin Filamentous Meshwork in the Keratinocyte

    December 2011 in “ Journal of Dermatological Science ”
    Takahisa Takase, Yohei Hirai
    Studysummary This study suggests that the C-terminal of AHF is crucial for its binding to keratin bundles and modulating the keratin meshwork in hair follicles.
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    Research cited in this study 13

    1. Identification of a Preferred Substrate Peptide for Transglutaminase 3 and Detection of In Situ Activity in Skin and Hair Follicles ˜The œFEBS journal · 2010
    2. Molecular Elements of the Regulatory Control of Keratin Filament Modulator AHF/Trichohyalin in the Hair Follicle Experimental Dermatology · 2008
    3. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    4. Comparative Aspects of the Inner Root Sheath in Adult and Developing Hairs of Mammals in Relation to the Evolution of Hairs Journal of Anatomy · 2004
    5. Fine Structure and Immunocytochemistry of Monotreme Hairs, with Emphasis on the Inner Root Sheath and Trichohyalin-Based Cornification During Hair Evolution Journal of morphology · 2004
    6. Epimorphin Acts to Induce Hair Follicle Anagen in C57BL/6 Mice The FASEB Journal · 2003
    7. A Small Deletion Hotspot in the Type II Keratin Gene mK6irs1/Krt2-6g on Mouse Chromosome 15, a Candidate for Causing the Wavy Hair of the Caracul (Ca) Mutation Genetics · 2003
    8. Trichohyalin Mechanically Strengthens the Hair Follicle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    9. Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency Journal of Investigative Dermatology · 2003
    10. Existence of Trichohyalin-Keratohyalin Hybrid Granules: Co-Localization of Two Major Intermediate Filament-Associated Proteins in Non-Follicular Epithelia Differentiation · 1994
    11. Keratohyalin, Trichohyalin, and Keratohyalin-Trichohyalin Hybrid Granules: An Overview The Journal of Dermatology · 1992
    12. Cyclic Hair Loss and Regrowth in Transgenic Mice Overexpressing an Intermediate Filament Gene The EMBO Journal · 1990
    13. Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986

    Related research 1

    1. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002