Keratosis Follicularis

April 1906 in “ The American Journal of the Medical Sciences ”

SAMBEBGER

Keratosis Pilaris Atrophicans follicular hyperkeratosis inflammation atrophy Atrophoderma Vermiculatum epidermis dermis scarring keratinization hair follicle synthetic retinoid KPA skin inflammation skin atrophy skin scarring retinoid

TLDR Keratosis Pilaris Atrophicans causes skin scarring and might be treated with a new synthetic retinoid.

The document discusses Keratosis Pilaris Atrophicans (KPA), a group of skin conditions characterized by follicular hyperkeratosis, inflammation, and atrophy. It classifies the disorders based on the location and severity of the lesions, with KPAF and KFSD affecting only the follicle, and Atrophoderma Vermiculatum also impacting the epidermis and dermis. These conditions typically begin in infancy and lead to scarring. Currently, there is no effective treatment, but the involvement of follicular hyperkeratosis suggests that KPA might be related to abnormal keratinization in the hair follicle. This insight has led to the consideration of a new synthetic retinoid for treatment, supported by a grant from the National Institutes of Health.

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