Keratosis Follicularis: Classification and Potential Treatments

    April 1906 in “ The American Journal of the Medical Sciences ”
    SAMBEBGER
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    TLDR Keratosis Pilaris Atrophicans causes skin scarring and might be treated with a new synthetic retinoid.
    The document discusses Keratosis Pilaris Atrophicans (KPA), a group of skin conditions characterized by follicular hyperkeratosis, inflammation, and atrophy. It classifies the disorders based on the location and severity of the lesions, with KPAF and KFSD affecting only the follicle, and Atrophoderma Vermiculatum also impacting the epidermis and dermis. These conditions typically begin in infancy and lead to scarring. Currently, there is no effective treatment, but the involvement of follicular hyperkeratosis suggests that KPA might be related to abnormal keratinization in the hair follicle. This insight has led to the consideration of a new synthetic retinoid for treatment, supported by a grant from the National Institutes of Health.
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      in Transgender  6 upvotes 11 months ago
      The user underwent a biopsy two years ago and was diagnosed with keratosis pilaris, leading to hair issues. They tried treatments including Minoxidil, betamethasone, lymecycline, topical Accutane, and dutasteride, as well as diet changes, without improvement in hair thickness or skin dryness.

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      in Treatment  9 upvotes 10 months ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

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      in Research/Science  11 upvotes 2 years ago
      The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

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      in Research/Science  98 upvotes 1 month ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

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