5-Alpha-Reductase 2 Inhibition Impairs Brain Defeminization of Male Rats: Reproductive Aspects

    September 2005 in “ Pharmacology Biochemistry and Behavior ”
    Camilla Moreira Ribeiro, Oduvaldo Câmara Marques Pereira
    Studysummary This study found that inhibiting the 5alpha-reductase 2 pathway in male rats affects brain sexual differentiation and leads to reproductive changes, including increased pre-implantation loss despite unchanged copulatory potential.
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    Research cited in this study 7

    1. Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility Biology of Reproduction · 2004
    2. Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment Neurobiology of Aging · 1995
    3. Finasteride The New England Journal of Medicine · 1994
    4. Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats Progress in Neuro-psychopharmacology & Biological Psychiatry · 1993
    5. Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor Toxicology and Applied Pharmacology · 1993
    6. Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation Reproductive Toxicology · 1991
    7. External Genitalia Abnormalities in Male Rats Exposed In Utero to Finasteride, a 5α-Reductase Inhibitor Teratology · 1990