A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in Neonatal Mouse Inner Ear Organoids

    March 2024 in “ PubMed ”
    Wenjin Wu, Penghui Chen, Jun Yang, Y K Liu
    Studysummary This study reported that rapamycin reduced murine cochlear organoid proliferation depending on concentration, but at a 10-nM dose, it significantly increased hair cell differentiation by enriching SOX2+ progenitors while suppressing cells lacking Sox2 at early proliferation stages.
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    Research cited in this study 1

    1. Rapamycin But Not Acarbose Decreases Age-Related Loss of Outer Hair Cells in the Mouse Cochlea Hearing research · 2018