Epidermal Growth Factor Upregulates Production of Supernumerary Hair Cells in Neonatal Rat Organ of Corti Explants

    January 2000 in “ Acta Oto-Laryngologica ”
    Philippe Lefèbvre, Brigitte Malgrange, Marc Thiry, Thomas R. Van De Water, Gustave Moonen
    TLDR Epidermal growth factor increases extra hair cells in newborn rat ears.
    The study investigated the potential for producing supernumerary hair cells in neonatal rat organ of Corti explants. It was found that the application of epidermal growth factor (EGF) led to a 50% increase in the length of the organ of Corti segment containing supernumerary hair cells. This upregulation was most effective at birth (P0) and ceased by 2 days after birth (P2). The production of these additional hair cells occurred independently of cell division, as demonstrated by treatment with the antimitotic drug cytosine arabinoside (ARAc). This research suggested that EGF could stimulate the formation of extra hair cells in more mature auditory sensory epithelia.
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