Association of Janus Kinase Inhibitors With Reduced Depression in Alopecia Areata

    November 2025 in “ Journal of the European Academy of Dermatology and Venereology ”
    Chih‐Yi Ho, Hsiang‐Ling Wu, Ying‐Xiu Dai … Ying‐Hsuan Tai
    Studysummary This study found that JAK inhibitor treatment in patients with alopecia areata was associated with a lower incidence of major depressive disorder and decreased antidepressant usage.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Efficacy and Safety of Deuruxolitinib, an Oral Selective Janus Kinase Inhibitor, in Adults with Alopecia Areata: Results from the Phase 3 Randomized, Controlled Trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024
    2. Psychosocial and Mental Impact of Alopecia Areata: Analysis of the Danish Skin Cohort Journal of the European Academy of Dermatology and Venereology · 2024
    3. Novel Investigational Drugs for Alopecia Areata and Future Perspectives Expert opinion on investigational drugs · 2024
    4. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    5. Janus Kinase Inhibitors For Alopecia Areata JAMA network open · 2023
    6. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    7. The Associated Burden of Mental Health Conditions in Alopecia Areata: A Population-Based Study in UK Primary Care British Journal of Dermatology · 2022
    8. A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021
    9. Bidirectional Association Between Alopecia Areata and Migraine: A Nationwide Population-Based Cohort Study Journal of the American Academy of Dermatology · 2020
    10. The Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata: A Systematic Review Dermatologic therapy · 2019
    11. Assessment of a Bidirectional Association Between Major Depressive Disorder and Alopecia Areata JAMA Dermatology · 2019
    12. Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata Drug design, development and therapy · 2018