Dermal-Epidermal Interactions in Hair Follicle Development and Maintenance

October 1996 in “ Dermatologic clinics ”

Colin A.B. Jahoda, Amanda J. Reynolds

androgenetic steroid hormones autoimmune attacks on hair follicles chemotherapy alopecia in vitro models laboratory animal models steroid hormones autoimmune hair loss hair loss due to chemotherapy hair loss lab models

Studysummary This chapter reviews laboratory models used for studying alopecia therapies but provides no new experimental findings.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts

11 citations , August 1995 in “Journal of Investigative Dermatology”

research Sheep Vibrissa Dermal Papillae Induce Hair Follicle Formation in Heterotypic Skin Equivalents

21 citations , December 1994 in “British Journal of Dermatology”

In this study, cultured skin equivalents with ovine hair follicle dermal papillae grafted onto nude mice developed follicle-like structures, suggesting a potential model for studying hair follicle development.

research Retinoic Acid and Mouse Skin Morphogenesis: Role of Epidermal Competence in Hair Glandular Metaplasia

16 citations , November 1994 in “Developmental Biology”

Retinoic acid causes gland formation instead of hair in mouse skin by altering epidermal and dermal interactions.

research Transfection of Rat Dermal Papilla Cells with a Gene Encoding a Temperature-Sensitive Polyomavirus Large T Antigen Generates Cell Lines Retaining a Differentiated Phenotype

25 citations , July 1994 in “Journal of Cell Science”

This study found that polyomavirus large T-immortalized rat dermal papilla cells retain hair-inductive ability and provide a viable model for studying hair growth and cytokine expression.

research Dynamic Expression Patterns of Tenascin, Proteoglycans, and Cell Adhesion Molecules During Human Hair Follicle Morphogenesis

67 citations , February 1994 in “Developmental dynamics”

This study analyzed the distribution of adhesion molecules and extracellular matrix components in human fetal skin, suggesting their roles in hair follicle development.

research Outer Root Sheath Cells Organize Into Epidermoid Cyst-Like Spheroids When Cultured Inside Matrigel: A Light-Microscopic and Immunohistological Comparison Between Human ORS Cells and Interfollicular Keratinocytes

36 citations , January 1994 in “Cell and Tissue Research”

research Soluble Factors From Human Hair Papilla Cells And Dermal Fibroblasts Dramatically Increase The Clonal Growth Of Outer Root Sheath Cells

62 citations , June 1993 in “Archives of Dermatological Research”

research Cellular and Extracellular Involvement in the Regeneration of the Rat Lower Vibrissa Follicle

39 citations , April 1992 in “Development”

In this study, researchers detailed how hair follicles regenerate after microsurgical amputation, observing a wound reaction involving dynamic dermal-epidermal interactions and changes in extracellular matrix components.

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.

research Coculture of Human Hair Follicles and Dermal Papillae in Type I Collagen Gel

7 citations , December 1991 in “Annals of the New York Academy of Sciences”

Dermal papillae are crucial for hair growth and maintenance.

research Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells

31 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study found that distinct keratin profiles enabled the evaluation of epithelial differentiation in human hair follicles, with mesenchymal cells playing a critical role in epidermoid differentiation of follicular cells.

research Epithelial Growth by Rat Vibrissae Follicles In Vitro Requires Mesenchymal Contact via Native Extracellular Matrix

66 citations , August 1990 in “Journal of Investigative Dermatology”

Epithelial cell growth in rat hair follicles needs contact with mesenchymal cells through the extracellular matrix.

research Studies of Developing Human Hair Shaft Cells In Vitro

25 citations , January 1988 in “Journal of Investigative Dermatology”

research Rat Hair Follicle Dermal Papillae Have an Extracellular Matrix Containing Basement Membrane Components

103 citations , December 1986 in “Journal of Investigative Dermatology”

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.