Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth

February 2023 in “ British Journal of Pharmacology ”

Sapna Sayed, Jiaxing Song, Ling Wang, Tobias Achu Muluh, Boxin Liu, Zhixian Lin, Yun Tang, Zijie Su, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Guangqian Zhou, Qi Sun, Desheng Lu

TLDR Isoxazole 9 (ISX9) may help regrow hair by activating certain cell signals.

The study identified Isoxazole 9 (ISX9) as a novel activator of the Wnt/β-catenin signaling pathway, crucial for hair growth and regeneration. ISX9 targeted Axin1, enhancing the LRP6-Axin1 association and stabilizing β-catenin, which promoted hair follicle proliferation and hair growth in C57BL/6 mice. The study found that ISX9 was more effective than minoxidil in promoting hair regrowth, with no significant adverse effects on major organs. ISX9 upregulated Wnt target genes and stemness marker genes, suggesting its potential as a therapeutic agent for alopecia treatment. Further studies were needed to evaluate its efficacy and safety in humans.

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