Invasion and increased expression of S100A4 and CYR61 in mesenchymal transformed breast cancer cells is downregulated by GnRH

The study demonstrated that S100A4 and CYR61 were crucial in promoting invasion and metastasis in mesenchymal transformed breast cancer cells. It was found that the expression of these proteins was significantly higher in MDA-MB-231 cells compared to MCF-7 cells, and their increased expression in mesenchymal transformed MCF-7 cells (MCF-7-EMT) could be reduced by antibodies targeting S100A4 and CYR61. Furthermore, treatment with the GnRH agonist Triptorelin significantly decreased both the invasion and expression of S100A4 and CYR61 in MCF-7-EMT and MDA-MB-231 cells. The study concluded that GnRH treatment could effectively inhibit the invasion and expression of these proteins, suggesting a potential therapeutic approach for breast cancer.