Systemic Inflammatory Biomarkers In Alopecia Areata: The Role Of SII, SIRI, And CRP/Albumin Ratio

    April 2025 in “ Dermatology Practical & Conceptual ”
    Işıl Deniz Oğuz, Sevgi Kulaklı, Burak Akşan
    TLDR Alopecia areata patients have higher systemic inflammation, even in mild cases.
    This study examined systemic inflammatory biomarkers in 118 alopecia areata (AA) patients compared to 122 healthy controls, focusing on the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and CRP/albumin ratio (CAR). The findings revealed that SII levels were significantly higher in AA patients (P<0.001), while SIRI and CAR levels showed no significant difference. Importantly, none of these biomarkers correlated with disease severity, suggesting that systemic inflammation is present even in mild cases of AA.
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