TLDR Alopecia areata patients have higher systemic inflammation, even in mild cases.
This study examined systemic inflammatory biomarkers in 118 alopecia areata (AA) patients compared to 122 healthy controls, focusing on the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and CRP/albumin ratio (CAR). The findings revealed that SII levels were significantly higher in AA patients (P<0.001), while SIRI and CAR levels showed no significant difference. Importantly, none of these biomarkers correlated with disease severity, suggesting that systemic inflammation is present even in mild cases of AA.
March 2024 in “Current issues in molecular biology” Personalized medicine in dermatology uses molecular biomarkers to improve diagnosis and treatment but needs further advancements for practical use.
March 2024 in “Skin research and technology” High CRP levels could indicate vitamin D deficiency in people with alopecia areata.
September 2023 in “Journal of Cosmetic Dermatology” Lower vitamin D levels are linked to higher CRP levels in people with a type of hair loss called alopecia areata.
4 citations
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April 2023 in “Autoimmunity reviews” High levels of IL6 and CRP, and low levels of vitamin D, might be indicators of alopecia areata.
3 citations
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October 2022 in “Journal of Cosmetic Dermatology” CAR is a useful marker for assessing alopecia areata severity.
148 citations
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December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
37 citations
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June 2018 in “Clinical and Experimental Medicine” People with alopecia areata often have lower vitamin D levels and more inflammation, suggesting vitamin D might be involved in the condition.
18 citations
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October 2014 in “Indian Journal of Dermatology”
April 2019 in “International journal of research in dermatology” A child with rough nails also had hair loss and allergies.
