Hematological Ratios in Pediatric Patients With Alopecia Areata Based on a Nationwide Retrospective Cohort Study

January 2026 in “ Scientific Reports ”

Cathy Gordon, Sarah Weissmann, Nicolás André, Bracha Cohen, Inbal Golan-Tripto, Amir Horev

alopecia areata eosinophil/lymphocyte ratio eosinophil/monocyte ratio eosinophil/neutrophil ratio AA

TLDR Certain blood cell ratios are higher in kids with alopecia areata and might help predict the disease.

A nationwide retrospective cohort study involving 31,869 pediatric patients with alopecia areata (AA) analyzed hematological ratios to assess their potential as markers for disease exacerbation. The study found that the eosinophil/lymphocyte ratio (ELR), eosinophil/monocyte ratio (EMR), and eosinophil/neutrophil ratio (ENR) were significantly elevated in patients with AA compared to healthy controls. Elevated ELR and ENR increased the likelihood of AA by 3.31 and 2.61 times, respectively. Severe AA patients showed increased ELR, ENR, and EMR, with elevated ENR observed 12–18 months before diagnosis. These eosinophilic ratios could serve as promising markers for studying the pathophysiology and predicting exacerbations of AA.

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Research cited in this study

research Scalp Hair Regrowth Is Associated With Improvements in Health-Related Quality of Life and Psychological Symptoms in Patients With Severe Alopecia Areata: Results From Two Randomized Controlled Trials

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research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research Alopecia Areata Update

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

research Early Stage Alopecia Areata Is Associated With Inflammation in the Upper Dermis and Damage to the Hair Follicle Infundibulum

research Eosinophils in Fibrous Tracts and Near Hair Bulbs: A Helpful Diagnostic Feature of Alopecia Areata

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