Hair Today, Gone Tomorrow: Potential of Tofacitinib and Ruxolitinib in Treating Hair Loss

    January 2016 in “ Chemistry & Industry ”
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    TLDR Two drugs, tofacitinib and ruxolitinib, may help regrow hair by activating hair follicles.
    The document discusses the potential of two drugs, tofacitinib and ruxolitinib, in treating hair loss. These drugs, originally used for rheumatoid arthritis and bone-marrow cancer respectively, block the janus kinase (JAK) family of enzymes, which are involved in immune responses. Researchers at Columbia University Medical Center found that these JAK inhibitors can induce rapid hair regrowth by kicking hair follicles into the active growth phase. This was observed in both mice and human hair follicles. Additionally, oral tofacitinib has been reported to reverse alopecia universalis in a patient with psoriasis. While the findings are promising, especially for alopecia areata, the document notes that the studies are small-scale and preliminary. The main challenge for using these drugs in the UK is their significant cost and safety concerns. The document also briefly mentions the 'holy grail' of hair loss treatment, which is hair follicle regeneration through stem cells, highlighting recent progress in this area.
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      community What else is good. Besides the big 3.

      in Chat  35 upvotes 7 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community No hair, don't care! [24/F] :)

       61 upvotes 9 years ago
      A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

      community IGE Hair Loss and Miniaturization

      in Chat  2 upvotes 1 month ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       6 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 7 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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