Hair Growth‐Promoting Effect of Carthamus tinctorius Floret Extract
December 2013
in “Phytotherapy Research”
TLDR Safflower (Carthamus tinctorius) extract helps hair grow and could be used in hair products.
The 2013 study demonstrated that Carthamus tinctorius extract (CTE) has hair growth-promoting effects, evidenced by in vitro and in vivo experiments. In vitro, CTE enhanced the proliferation of dermal papilla cells and HaCaT keratinocytes, upregulated the expression of hair growth-promoting genes VEGF and KGF, and downregulated the hair loss-related gene TGF-β1. In vivo, CTE increased hair follicle length in cultured mouse neonates and stimulated hair regrowth on shaved female C57BL/6 mice, increasing the number of hair follicles and the anagen phase ratio without causing skin irritation. These effects were comparable to the positive control, minoxidil. The extract contained a high amount of hydroxysafflor yellow A (HSYA), suggesting its potential use in hair growth-promoting products. The study was supported by the National Nanotechnology Center (NANOTEC), Khon Kaen University, and the National Research Council of Thailand.
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