Fate Before Function: Specification of the Hair Follicle Niche Occurs Prior to Its Formation and Is Progenitor Dependent

    Ka‐Wai Mok, Nivedita Saxena, Nicholas Heitman, Laura Grisanti, Devika Srivastava, Mauro J. Muraro, Tina Jacob, Rachel Sennett, Zichen Wang, Yutao Su, Lu Yang, Avi Ma’ayan, David M. Ornitz, Maria Kasper, Michael Rendl
    The study demonstrated that the specification of dermal condensates (DC), which are signaling niches for epithelial progenitors in hair placodes, occurred before the actual formation and function of the niche. Using advanced microscopy and transcriptomics, researchers identified unclustered DC precursors and mapped the molecular changes as the DC lineage developed from fibroblasts. A transitional molecular state was observed, characterized by the co-expression of downregulated fibroblast and upregulated DC genes following a proliferation shutdown. The formation of the DC niche was consolidated through successive waves of transcription factor and signaling molecule expression. The study also found that epidermal Wnt signaling and placode-derived FGF20 were crucial for the specification of DC precursors, indicating that niche fate acquisition was progenitor-dependent and not pre-programmed.
    Discuss this study in the Community →

    Research cited in this study

    21 / 21 results

    Related Research

    1 / 1 results