Fate Before Function: Specification of the Hair Follicle Niche Occurs Prior to Its Formation and Is Progenitor Dependent

    Ka‐Wai Mok, Nivedita Saxena, Nicholas Heitman, Laura Grisanti, Devika Srivastava, Mauro J. Muraro, Tina Jacob, Rachel Sennett, Zichen Wang, Yutao Su, Lu Yang, Avi Ma’ayan, David M. Ornitz, Maria Kasper, Michael Rendl
    TLDR Hair follicle niches are specified before they form and depend on progenitor cells.
    The study demonstrated that the specification of dermal condensates (DC), which are crucial signaling niches for epithelial progenitors in hair placodes, occurred before the actual formation and function of the niche. Using advanced microscopy and transcriptomics, researchers identified unclustered DC precursors and mapped the molecular timeline of niche development from fibroblasts. They discovered a transitional molecular state characterized by the co-expression of downregulated fibroblast and upregulated DC genes, following a halt in proliferation. Successive waves of transcription factor and signaling molecule expression were found to solidify DC niche formation. The study also highlighted the necessity of epidermal Wnt signaling and placode-derived FGF20 for the specification of DC precursors, indicating that niche fate acquisition was not pre-programmed but depended on progenitor signals.
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