Hierarchical patterning modes orchestrate hair follicle morphogenesis
July 2017
in “
PLoS Biology
”
Research cited in this study
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LHX2 is essential for hair follicle development, controlled by NF-κB and TGFβ2 signaling.
research An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin
The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.
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The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.
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Two fibroblast types shape skin structure and repair differently.
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research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation
Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
research Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
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EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.
research Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate
Activating β-catenin can turn skin cells into hair follicles.
research Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes
Ectodysplasin inhibits Wnt signaling to help form hair follicles.
research The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis
The study found that the protein Dkk4 helps regulate hair growth by controlling Wnt signaling in mice.
research Molecular Principles of Hair Follicle Induction and Morphogenesis
Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
research Morpho-Regulation of Ectodermal Organs
Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.
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Hair follicles create different cell layers and proteins, controlled by various molecules.