Hair Aging As An Urgent Problem Of Modern Medicine

July 2025 in “ Vrach ”

S. Ledentsova, P. Seliverstov, E. Shenderovich

hair aging graying of hair minoxidil 5-alpha reductase inhibitors nutrient absorption disorders endocrine diseases Osteomed Osteo-Vit D3 Rogaine

Studysummary This article discusses the lack of effective drugs for treating graying hair and explores current therapies for age-related hair changes, emphasizing the importance of addressing general health issues and nutrient supplementation for hair health.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The article addresses the urgent issue of hair aging, particularly the graying of hair and the lack of effective treatments for it. It highlights the importance of tackling age-related health problems that impact hair, such as nutrient absorption disorders, endocrine diseases, and psychological issues. Current treatments for hair loss include minoxidil and 5-alpha reductase inhibitors. The article also points out the critical role of nutrients in maintaining hair health, suggesting that Russian products like Osteomed and Osteo-Vit D3 could be promising sources of these nutrients.

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Research cited in this study

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research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations , December 2018 in “Dermatology and Therapy”

This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.

Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials

research Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials

41 citations , December 2018 in “Experimental Dermatology”

This review explores recent findings on the roles of melanocyte and melanocyte stem cells in the hair follicle, highlighting their importance for skin health and potential applications in regenerative medicine, but reports no new clinical results.

research Minoxidil for Endocrine Therapy–Induced Alopecia in Women With Breast Cancer—Saint Agatha’s Blessing?

9 citations , April 2018 in “JAMA Dermatology”

This abstract provided no research findings as it contains only website navigation and service information.

research Hair Repigmentation Associated With the Use of Brentuximab

15 citations , November 2017 in “JAAD Case Reports”

This study reports no known changes in hair pigmentation associated with brentuximab vedotin, despite its various other documented adverse effects.

research Repigmentation of Hair Following Adalimumab Therapy

17 citations , January 2015 in “Dermatology online journal”

This report describes a patient experiencing hair repigmentation linked to adalimumab therapy, a TNF inhibitor, a phenomenon not previously associated with this class of drugs.

research Premature Graying of Hair: Causes, Associations, and Treatments

47 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

This review examines the pathogenesis of premature hair graying and potential treatment avenues, but reports no new experimental outcomes, highlighting ongoing research challenges and hopes for drug development.

research Characteristic Microstructure of Curved Human Hair

4 citations , July 2010 in “International Journal of Cosmetic Science”

This study observed that hair fibers in older women become more curved with age, decreasing hair luster due to their disordered alignment and structural differences between the convex and concave sides.

research Aging of Hair

99 citations , June 2005 in “Journal of Cosmetic Dermatology”

This article reviews factors influencing hair aging and available treatments like minoxidil and finasteride for androgenetic alopecia but reports no new clinical results.

research Nestin Expression in Hair Follicle Sheath Progenitor Cells

352 citations , August 2003 in “Proceedings of the National Academy of Sciences”

In this study, nestin-expressing cells in the hair follicle bulge, marked by GFP in transgenic mice, were identified as progenitors of the hair follicle outer-root sheath.

research Hair Darkening in Porphyria Cutanea Tarda

38 citations , February 2002 in “British journal of dermatology/British journal of dermatology, Supplement”

This report describes two cases of sustained hair repigmentation related to porphyria cutanea tarda, though the underlying mechanism remains unclear.

research Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss

234 citations , February 2001 in “British Journal of Dermatology”

FPHL affects hair density and diameter, causing visible hair loss in older women.

research The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness

143 citations , October 1988 in “Clinics in Dermatology”

This review discusses the histopathology of male-pattern baldness and highlights ongoing disputes over several aspects, including sebaceous gland size and follicle loss, reporting no new clinical findings.

research Alopecia

22 citations , June 1980 in “International Journal of Dermatology”

The document concludes that correct diagnosis of alopecia types is crucial, scalp biopsies are important, and more research is needed.