A Genome-Wide Association Study Identified a Genetic Variant Associated With Hair Thinning in Japanese Women

March 2023 in “ Journal of Cosmetic Dermatology ”

Ryosuke Okuno, Toshio Igarashi, Yuichi Hasebe, Mika Kawagishi‐Hotta, Seiji Hasegawa

genome-wide association study single nucleotide polymorphisms SNPs rs2419385 clathrin interactor 1 CLINT1 tRNA-histidine guanylyltransferase 1 like THG1L transforming growth factor beta signaling hair thinning GWAS TGF-beta signaling

TLDR A genetic variant linked to hair thinning in Japanese women was found.

A genome-wide association study (GWAS) was conducted to identify single nucleotide polymorphisms (SNPs) involved in hair thinning in Japanese women. The study involved 1040 women aged 21–95 years and identified rs2419385 as a SNP with the strongest signal associated with hair thinning. When the analysis was performed on middle-aged women (926 women aged 30–69 years), rs2419385 still fulfilled the genome-wide significance level. Genes near rs2419385, including clathrin interactor 1 (CLINT1) and tRNA-histidine guanylyltransferase 1 like (THG1L), were suggested to be involved in the expression of rs2419385. Both genes have been suggested to play a role in transforming growth factor beta signaling, which is known to negatively regulate hair growth. Future studies are needed to investigate the roles of these genes in hair thinning in more detail.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Cited in this study

3 / 3 results

research Early Onset Female Pattern Hair Loss: A Case-Control Study for Analyzing Clinical Features and Genetic Variants

3 citations , February 2022 in “Journal of Dermatological Science”

research Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population

7 citations , July 2015 in “Dermatology”

Two gene variations, rs6493497 and rs7176005, may be linked to female hair loss in Chinese people.

research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

77 citations , August 2009 in “British Journal of Dermatology”

Aromatase gene variation may increase female hair loss risk.

7 / 7 results

research Clinical Trial Efficacy of Autologous Cellular Micrografts in Androgenic Alopecia

February 2023 in “Research Square (Research Square)”

research Pharmacological Therapeutics in Androgenetic Alopecia

3 citations , May 2020 in “Journal of The Korean Medical Association”

research Finasteride in the Treatment of Female Androgenic Alopecia

November 2014 in “PharmaTutor”

Finasteride may help postmenopausal women with hair loss but is not effective for all and should be used cautiously in premenopausal women.

research Hair Biology and Its Comprehensive Sequence in Female Pattern Baldness: Diagnosis and Treatment Modalities - Part I

1 citations , April 2013 in “PubMed”

The document concludes that female pattern baldness involves hair thinning, is classified differently than in men, and is assessed using the Ludwig classification. It also explains the hair growth cycle stages.

research Male Pattern Baldness: An Update

January 2009 in “Revista de Ciências Médicas”

Male pattern baldness is a genetic condition causing hair loss, with limited but improving treatment options.

research Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies

10 citations , June 2001 in “PubMed”

Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.

research Male Pattern Alopecia: Impact on Self-Esteem and Evolution of Hair Restoration Surgery

2 citations , October 1997 in “Dermatologic Clinics”

The document concludes that advancements in hair restoration surgery have led to more natural results and patient satisfaction, with hope for future improvements in treatment.