Hepatotoxicity with Low- and Ultralow-Dose Flutamide: A Surveillance Study on 203 Hyperandrogenic Young Females

    July 2012 in “ Fertility and Sterility ”
    Vincenzina Bruni, Elena Peruzzi, Metella Dei … Massimiliano Fambrini
    Studysummary This study observed that hepatotoxicity is a rare but possible event in hyperandrogenic young females treated with low- and ultralow-dose flutamide, regardless of dose or oral contraceptive use.
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    Research cited in this study 6

    1. Polycystic Ovary Syndrome: Comprehensive Overview and Diagnostic Criteria The Lancet · 2007
    2. Hirsutism New England journal of medicine/˜The œNew England journal of medicine · 2005
    3. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004
    4. A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism The Journal of Clinical Endocrinology and Metabolism · 1999
    5. Hepatotoxicity Complicating Flutamide Treatment of Hirsutism Annals of internal medicine · 1993
    6. Incidence of Liver Toxicity Associated with the Use of Flutamide in Prostate Cancer Patients The American Journal of Medicine · 1992