Formulation and Evaluation of Nanogel Containing Quercetin for Treatment of Alopecia

The study developed Quercetin-loaded nanogel formulations to improve drug delivery and therapeutic efficacy for alopecia treatment. Nine batches of Quercetin nanoparticles were evaluated, showing good colloidal stability with zeta potential values from -5.45 mV to -17.65 mV and spherical morphology. The optimized batch achieved a 95.32% drug release over 12 hours. The nanoparticles were converted into a gel with suitable pH, viscosity, and spreadability for topical use. Stability studies confirmed the formulation's integrity and sustained drug release, indicating that Quercetin-loaded nanogels are a promising platform for alopecia treatment.