A First Case of Childhood Chronic Inflammatory Demyelinating Polyneuropathy Associated with Alopecia Universalis

August 2022 in “ Brain and Development ”

Yukimune Okubo, Takuya Miyabayashi, Ryo Sato, Wakaba Endo, Takehiko Inui, Noriko Togashi, Kazuhiro Haginoya

alopecia universalis chronic inflammatory demyelinating polyneuropathy intravenous immunoglobulin corticosteroids IgG-GM2 type anti-glycolipid antibodies AU CIDP IVIg

TLDR A nine-year-old girl with muscle weakness and total hair loss improved with specific treatments.

This document reports the first case of a nine-year-old Japanese girl with childhood chronic inflammatory demyelinating polyneuropathy (CIDP) associated with alopecia universalis (AU). The girl developed alopecia at age 2, progressive muscle weakness at age 4, and lost her ability to walk by age 7. She was successfully treated with a combination of intravenous immunoglobulin (IVIg) and prednisolone, which improved both her muscle weakness and alopecia. The presence of serum IgG-GM2 type anti-glycolipid antibodies in the patient may be linked to this rare combination of diseases.

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