A First Case of Childhood Chronic Inflammatory Demyelinating Polyneuropathy Associated with Alopecia Universalis

    August 2022 in “ Brain and Development ”
    Yukimune Okubo, Takuya Miyabayashi, Ryo Sato, Wakaba Endo, Takehiko Inui, Noriko Togashi, Kazuhiro Haginoya
    Studysummary In this case report, a nine-year-old girl with both chronic inflammatory demyelinating polyneuropathy and alopecia universalis showed improvement in muscle weakness and hair loss after treatment with intravenous immunoglobulin and corticosteroids. Our plain-language summary of this paper — not a Tressless recommendation.
    This document reports the first case of a nine-year-old Japanese girl with childhood chronic inflammatory demyelinating polyneuropathy (CIDP) associated with alopecia universalis (AU). The girl developed alopecia at age 2, progressive muscle weakness at age 4, and lost her ability to walk by age 7. She was successfully treated with a combination of intravenous immunoglobulin (IVIg) and prednisolone, which improved both her muscle weakness and alopecia. The presence of serum IgG-GM2 type anti-glycolipid antibodies in the patient may be linked to this rare combination of diseases.
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