Evaluation of Androgen Receptor Gene as a Candidate Gene in Female Androgenetic Alopecia

March 2009 in “ International Journal of Dermatology ”

May El-Samahy, Maha Adel Shaheen, Dina E. B. Saddik, Nermeen S.A. Abdel Fattah, Mohammad A. El-Sawi, Manal Z. Mahran, Abeer A. Shehab

androgen receptor gene female androgenetic alopecia androgenetic alopecia AR gene polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP genotype allele frequency androgen receptor female pattern hair loss PCR

TLDR The androgen receptor gene doesn't help identify women likely to have female pattern hair loss.

The 2009 study "Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia" investigated the role of the androgen receptor (AR) gene in female androgenetic alopecia (AGA). The study involved 30 premenopausal Egyptian women with AGA and 11 age- and sex-matched controls. The AR gene was evaluated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results showed no significant difference in genotype or allele frequency between patients and controls, and no significant correlation between genotype and allele frequency with disease duration. The study concluded that, unlike in male AGA, there was no association between type II AGA in Egyptian women and the AR gene, suggesting that this gene does not serve as a biomarker for identifying women predisposed to AGA.

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