Estrogen and Progesterone Receptors in Androgenic Alopecia Versus Alopecia Areata

April 1998 in “ American Journal of Dermatopathology ”

Michael B. Wallace, Bruce R. Smoller

androgenic alopecia alopecia areata estrogen receptor progesterone receptor immunohistochemical staining pilosebaceous units mesenchymal cells ER PR

TLDR Estrogen and progesterone don't directly affect hair growth in androgenic alopecia and alopecia areata.

The study conducted 25 years ago compared the immunohistochemical staining characteristics of nine cases of androgenic alopecia with those of 13 cases of alopecia areata using estrogen receptor (ER) and progesterone receptor (PR) markers. The results indicated that estrogen and progesterone receptor expression is not significantly increased or decreased in the pilosebaceous units or surrounding mesenchymal cells in androgenic alopecia vs. alopecia areata. Therefore, it was concluded that an indirectly mediated process of estrogen/progesterone control on hair growth and development must be presumed for cases of androgenic alopecia.

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Estrogen and progesterone don't directly affect hair growth in androgenic alopecia and alopecia areata.