Enhancement of follicular delivery of finasteride by liposomes and niosomes
October 2006
in “International Journal of Pharmaceutics”
TLDR Liposomes and niosomes improve finasteride delivery for hair loss treatment.
The study investigated the use of liposomes and niosomes to enhance the delivery of finasteride to hair follicles. The results showed that liquid-state liposomes and niosomes were able to deposit significantly higher amounts of the applied dose to the pilosebaceous unit compared to gel-state vesicles or hydroalcoholic solution. The study suggests that the use of liposomes and niosomes could be a promising approach for delivering finasteride topically to treat hair loss.
View this study on sciencedirect.com →
Cited in this study
research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles
Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.
research Use of Finasteride in the Treatment of Men With Androgenetic Alopecia (Male Pattern Hair Loss)
Finasteride effectively improves hair growth and slows hair loss in men with male pattern baldness.
research Permeant lipophilicity and vehicle composition influence accumulation of dyes in hair follicles of human skin
Lipophilic dyes accumulate more in hair follicles when delivered with surfactant-propylene glycol solutions.
research Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle
Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.
research Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro
Drugs penetrate scalp skin better than abdominal skin, with scalp hair follicles aiding in higher drug delivery.
research Treatments for Androgenetic Alopecia and Alopecia Areata
Minoxidil and finasteride treat hair loss; more research needed for other options.
research Finasteride in the treatment of men with androgenetic alopecia
Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.
research Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes
Sebaceous glands in the skin play a key role in absorbing the antiandrogen drug RU 58841, especially when it's encapsulated in liposomes.
research Topical finasteride in the treatment of androgenic alopecia. Preliminary evaluations after a 16-month therapy course
Topical finasteride helps regrow hair and reduce balding without side effects.
research Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
Finasteride effectively blocks enzyme causing male pattern baldness.
research Percutaneous absorption of a new antiandrogen included in liposomes or in solution
Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.
research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity
Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.
research A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women
research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism
research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness
Related
research Liposomes and niosomes as potential carriers for dermal delivery of minoxidil
Liposomes better deliver minoxidil for hair loss treatment than niosomes.
research Enhancement of follicular delivery of finasteride by liposomes and niosomes
Liposomes and niosomes improve finasteride delivery for hair loss treatment.