Expression of EGF, IGF-I, and IGF-IR Gene in Mink's Skin and Hair Follicles During Pelting Period

January 2014 in “ China Animal Husbandry & Veterinary Medicine ”

Zhang Hai-hu

New to Epidermal Growth Factor? There is a guide in the encyclopedia. Read the guide →

epidermal growth factor insulin-like growth factor I insulin-like growth factor I receptor hair follicles epidermal cells outer root sheath cells EGF IGF-I IGF-IR

Studysummary This study found that EGF, IGF-Ⅰ, and IGF-Ⅰ R are extensively expressed in mink skin and hair follicles, suggesting these genes play crucial roles in their development.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer ·

The study investigated the expression of epidermal growth factor (EGF), insulin-like growth factor I (IGF-I), and its receptor (IGF-IR) in mink skin and hair follicles during the pelting period using histological methods and immunohistochemistry. It found strong positive expression of these genes in the epidermal cells and outer root sheath cells, primarily located in the cell nuclei. The widespread expression of these genes suggested they played a crucial role in the regulation and development of mink skin and hair follicles.

View this study on en.cnki.com.cn →

Discuss this study in the Community →

Related Research

10 / 10 results

research 7-Phloroeckol Promotes Hair Growth on Human Follicles In Vitro

17 citations , May 2014 in “Naunyn-Schmiedeberg's Archives of Pharmacology”

In this study, 7-phloroeckol, derived from marine brown algae, was found to promote hair growth by increasing cell proliferation and hair shaft elongation in cultured human hair follicles.

research Influences of IGF-1 and EGF on Primary Hair Follicles of Liaoning Cashmere Goat In Vitro

1 citations , January 2010 in “Shenyang Nongye Daxue xuebao”

This study found that combining IGF-1 and EGF in specific concentrations significantly stimulated hair follicle growth in vitro for primary follicles from Liaoning cashmere goats.

research Effects of IGF-I and EGF on In Vitro Growth of Hair Follicles of Sheep

January 2006

This study found that treating sheep hair follicles with IGFⅠ and EGF stimulated growth, with EGF also accelerating cell differentiation and altering the growth cycle.

research Effects of Substance P on the Expression of Various Factors to Control Hair Growth in Human Hair Follicle Culture

1 citations , January 2004 in “Linchuang pifuke zazhi”

This study found that while SP did not enhance linear hair growth in cultured hair follicles, it prolonged the anagen phase and altered the expression of growth factors and apoptosis-related molecules, suggesting a stimulatory effect on hair growth.

research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia Upon Cyclooxygenase-2 Overexpression

41 citations , September 2003 in “Journal of Investigative Dermatology”

This study suggests that the COX-2 enzyme plays a role in hair follicle biology, as transgenic overexpression in mice induced hair follicle cycling disturbances and alopecia, which was mitigated by COX-2 inhibition.

research Keratin 14 in Skin and Hair Follicle of Rats During Postnatal Development Period

January 2001 in “Acta Academiae Medicine Militaris Tertiae”

In this study, the researchers reported that the expression of keratin 14 in the skin and hair follicles of neonatal and juvenile rats differs from that observed in adults or human embryos.

research Effects of Epidermal Growth Factor on Human Hair Follicle Growth In Vitro

April 2000 in “Chinese Journal of Dermatology”

This study found that epidermal growth factor may stimulate the growth of hair follicle epithelium and potentially accelerate the transition from anagen to catagen phase in cultured human hair follicles.

research Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development

107 citations , June 1997 in “PubMed”

In this study, disrupting the epidermal growth factor receptor in mice led to abnormal hair and skin development, characterized by disorganized hair follicles and systemic disease, providing a model for understanding EGFR's role in skin biology.

research An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation

154 citations , October 1996 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that 17-beta-estradiol inhibits hair growth in mice by blocking hair follicles in the telogen phase, whereas an estrogen receptor antagonist promotes hair growth by initiating anagen.

research Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle

112 citations , August 1984 in “Journal of Investigative Dermatology”